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Leading experts say the relationship between psychiatric drugs and weight gain isn’t being taken seriously enough by doctors.
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Pyrrole Disorder and Weight Gain. – A Healthy Meal
Does Pyrrole Disorder cause weight gain? … Pyroluria: Blood Sugar, Digestive Health & Thyro; Pyroluria, Stress & Weight Gain; Warning!
Source: ahealthymeal.com
Date Published: 8/20/2022
View: 5193
Could it be possible i have Pyrroles Disorder and not know it?
Pyrrole disorder is known by many other names such as mauve factor, pyrolouria, … Stretch marks (even without a large weight gain or loss).
Source: www.lifestylehealth.com.au
Date Published: 8/23/2022
View: 4859
Pyrrole Disorder (Pyroluria) – everything you need to know
People who have Pyrrole Disorder, produce excessive amounts of these Pyrroles which then bind to or stop use of Zinc, Vitamin B6 and Omega-6 fat …
Source: www.drcarrierigoni.com.au
Date Published: 3/18/2022
View: 3571
Kryptopyrrols Quiz – Pyroluria reduces your absorption of zinc …
Fatigue, weight gain, flu retention, hormone imbalance, depression and anxiety, … Pyroluria is simple to treat, with a rap response time, …
Source: advancedwellness.com.au
Date Published: 5/20/2021
View: 7874
Pyroluria and Adrenal Fatigue Syndrome – Dr. Lam Coaching
Pyroluria is a health issue with myany symptoms resembling those of adrenal fatigue. These include autism, ADHD, anxiety, and depression.
Source: www.drlamcoaching.com
Date Published: 3/25/2021
View: 8684
Pyrrole Disorder: Symptoms, Causes, Diagnosis & Treatment
Pyrrole disorder is a clinical condition that causes dramatic shifts in mood. It sometimes occurs alongse other mental health conditions.
Source: www.healthline.com
Date Published: 12/24/2022
View: 2296
What to Avoid Having Pyroluria Disorder » Eat For Life
Omega 3 Use in Pyrrole Disorder Increases Inflammation … Blood sugar dysregulation; Lack of regular menstrual cycles; Abnormal body fat distribution; Acne …
Source: eatfor.life
Date Published: 3/3/2022
View: 2746
Pyrrole disorder: boy’s erratic behaviour caused by rare health …
For a long time I’ve felt weird and crazy, but now I’m starting to feel like me again. I can’t remember the last time I felt like this, …
Source: www.kidspot.com.au
Date Published: 2/29/2021
View: 7745
MTHFR gene could be the cause of Weight Gain or prevent …
Pyrrole Disorder is a condition that can contribute and cause many mental health-related symptoms including anxiety and depression. At our Perth …
Source: advancedfunctionalmedicine.com.au
Date Published: 12/20/2021
View: 9056
Pyroluria – Complementary Compounding Services
Also known as pyrrole disorder, Pyroluria is a genetic chemical imbalance that involves a haemoglobin synthesis abnormality. This disorder can lead to a range …
Source: custommedicine.com.au
Date Published: 3/25/2022
View: 3804
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주제와 관련된 더 많은 사진을 참조하십시오 How psychiatric drugs can cause weight gain. 댓글에서 더 많은 관련 이미지를 보거나 필요한 경우 더 많은 관련 기사를 볼 수 있습니다.
주제에 대한 기사 평가 pyrrole disorder and weight gain
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- Date Published: 2017. 7. 14.
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Can pyrrole disorder be cured?
There’s no current cure for pyrrole disorder, but proper nutrition and stress management may help manage it.
How long does it take to cure Pyroluria?
Indeed, many patients find relief within days and most recover fully within 3-6 months with appropriate therapies. Since it is genetically-based, pyroluria is a chronic condition that requires lifelong treatment. Those who discontinue treatment generally experience an immediate return of their symptoms.
How common is pyrrole disorder?
Pyrrole Disorder is a relatively unknown condition, despite how many people would be suffering with it. It affects around 10% of the population, and in those suffering with other mental health issues, including schizophrenia, the prevalence is even higher.
How do I know if I have Pyroluria?
Pyroluria is diagnosed by a simple urine test which detects KPU in urine. Clinically speaking, I see many more women and children diagnosed with Pyroluria. It appears to be more common in women with red hair and fair skin, though there’s no research to back this up.
Pyrrole Disorder and Weight Gain.
Does Pyrrole Disorder cause weight gain? I’m pretty sure it does for me as one of the symptoms of Pyrrole Disorder (also known as Pyroluria) is unusual fat distribution.
For most of my life (certainly my entire adult life), my weight has been an issue and I’ve been all sorts of sizes and shapes, from a seriously obese junk food addict to a skinny but very flabby vegan.
But if we take a look at other problems caused by Pyroluria, it becomes blatantly obvious that this disorder can certainly impact one’s weight and thus cause a weight gain.
This post is about the author’s personal experience with Pyroluria and how she has dealt with it. The reader is strongly advised to seek counsel from a medically trained professional regarding this condition before embarking on any of the recommendations or suggestions mentioned in this article.
Pyroluria: Blood Sugar, Digestive Health & Thyroid
Blood sugar issues are common in pyroluria, as are digestive problems. Both of these can certainly have an influence on weight gain, or weight loss, depending on the individual in question. I know for myself, I had blood sugar problems when I was much younger (before I cleaned up my diet), and I still do without too much deviation from my (now) normal diet. I’ve also had a life filled with digestive issues, hormonal issues, and thyroid problems. These all can and do impact my weight. However, all of these health challenges are now much improved since starting on supplements for pyroluria four years ago and I have written these tips for managing pyrrole disorder.
Pyroluria, Stress & Weight Gain
I remember first noticing in my twenties that when I was happiest and not stressed, I lost weight. When I was unhappy, I gained. This confused me because for many of my friends their experience was opposite to mine. But now I know that the bodily happenings caused by Pyroluria explain why. The already exaggerated stress response that results from untreated Pyroluria simply becomes more exaggerated with additional stress or unhappiness, making hormonal and digestive problems worse, and creating weight gain.
Makes sense to me…I’ve also realized over this last year how easily my (already dodgy) detoxification pathways can get messed up, and how much that can impact my weight! Let me explain…
Warning! Some Supplements Can Cause Havoc
I was introduced to an unusual supplement 18 months ago by a Naturopath I met. She seemed to know her stuff, had Pyroluria herself and seemed to have a great understanding of methylation, plus she was really, really good with big words. The stories she shared were amazing! So I started taking the supplement she told me everyone over 40 should be on and truly thought it was a great idea. I waited for miracles…
But for me, things didn’t go quite as planned. Instead, I gained weight – over 15 kilos in about 3 months!
The problem was that I didn’t realize at the time how much I’d gained. I could feel that I’d suddenly gained some weight, but I’d told hubby to hide the scales after decided I was far too obsessed with them, and so I didn’t actually realize how much weight I’d packed on until several months later when I finally brought the scales out of hiding and weighed myself. And I didn’t put two and two together until much later on after developing rashes on my back and on my arms, and my skin began to look really bad. I also began to realize that I was gradually feeling worse – emotionally and physically.
I stopped taking that supplement that day. I looked terrible! My face was swollen and round with excess cortisol – my eyes had almost disappeared into my face. I hadn’t looked like that, or been that weight, for about 25 years.
That was last November (5 months ago now) and I’m still recovering. The rashes are almost gone and I’m working on the weight gain… When I mentioned my thoughts to the naturopath that sold me on the stuff, her answer was that it was probably messing with my detoxification pathways… Oops!
Probably. 👿
HCG Diet To The Rescue!
So there I was. Weighing in at over 100 kilos. A weight I never thought I’d reach again.
My heaviest weight ever was around 120 kilos in my late twenties. This was prior to quitting smoking at age 30, starting some regular (if somewhat obsessive) exercise, then gradual experimentation with new ways of eating, and the subsequent loss of a massive 45 kilos over 4 years. Since then my weight has mostly been somewhere between 75 and 85 kilos – for 25 years – until now.
And so I’ve reverted to the only way that I know works for me to lose weight now – the HCG diet (or 4 Phase Fat Elimination Protocol). It’s fast and it worked for me.
The HCG diet is a tough diet. It messes with your head a bit, but I’ve been successful with it in the past. However, I’ve been unable to stick to it for more than a week since starting on Pyroluria supplements four years ago because I’ve found that each time I’ve tried, I’ve fallen into a really dark, crying beside myself with misery and unable to get out, kind of depression. And so each time I tried, I ended up stopping to save my (and hubby’s) sanity, and I decided a couple of years ago that I wasn’t going to try anymore. Not until something changed that I have detailed here in my pyroluria diagnosis two years update.
I’m pleased to say that this time is different. I’m not sure if it’s just that I’ve been on supplements longer, or whether it’s because I’m using essential oils to support myself both emotionally and physically, but it’s working. I’ve lost 6kg in 3 weeks, having a few days off as I write this post, and then going back on in a couple of days for another 2 or 3 weeks.
Could it be possible i have Pyrroles Disorder and not know it?
A question we are being asked frequently these days is ‘What is Pyrrole Disorder?
Pyrrole disorder is known by many other names such as mauve factor, pyrolouria, and kryptopyroluria or kryptopyrole disorder.
How does Pyrroles work?
This abnormality, results in an over production of hydroxyhempyrolin (HPL). The HPL accumulates and binds to zinc and B6, preventing their use in the body.
Essentially we become Zinc and B6 Deficient , wreaking Havoc
Environmental, emotional and physical stress will increase the production of HPL, which will lead to zinc and B6 being excreted from the body via the urine and hair.
What sort of symptoms would I be feeling if I can’t utilise my bodies B6 or Zinc?
Good Questions, there is a long list of symptoms associated with pyrroles, however some of the more common symptoms are:
White spots on the fingernails
Irritable bowel syndrome
Pale skin, poor tanning or burn easily in the sun
Anxiety / withdrawal
Low stress tolerance
Mood swings / explosive anger / tantrums / aggression / argumentative
Depression
Insomnia
Poor or no dream recall
Fatigue
Hyperactivity / irritability
Craving for high-sugar and high carbohydrate foods
Poor morning appetite / tendency to skip breakfast
Frequent infections
Allergies
Stretch marks (even without a large weight gain or loss)
Anemia
Ok, I have some symptoms, what else would I look for?
There are also certain conditions, which are associated with Pyrrole disorder. Some of the more common conditions are:
ADD/ADHD
Depression
Allergies
Bipolar Disorder
Learning difficulties
Post natal depression
Heavy metal toxicity
Migraines
Pyrroles can be diagnosed by a simple urine test, which detects KPU in the urine.
Supplementation of certain nutrients will help to reduce the HPL levels detected in your urine sample as well as decrease the severity of conditions, signs and symptoms.
Our practitioners will be able to arrange for pyrrole testing to be done through QML or Sullivan & Nicolaides and also advise a treatment plan depending on your urine and blood test results.
#Depression #MTHFR #PyrrolesDisorder #anxiety #adrenalfatigue #Sleep #hormones #Weightloss #Fatigue
everything you need to know — Dr. Carrie Rigoni : Chiropractor Perth
How does Pyrrole Disorder occur?
All cells in your body produce waste or by-products. The by-product of haemoglobin is called hydroxyhemopyrrolin-2-one (HPL) also known as Pyrrole. People who have Pyrrole Disorder, produce excessive amounts of these Pyrroles which then bind to or stop use of Zinc, Vitamin B6 and Omega-6 fat GLA. Thus, these nutrients cannot be used by the body.
There are three main nutrients that are not properly absorbed in someone with pyrrole disorder. These are vitamin B6, magnesium, and zinc.
B6 in particular is necessary for the creation of red blood cells. It increases energy levels and proper cognitive function. A deficiency of B6 will often cause inflammation, depression, and sometimes anaemia.
Magnesium is often used as a muscle relaxant for athletes and is strongly involved in the blood sugar cycle. A deficiency can be the cause of blood sugar or appetite control issues, sleeplessness, constipation, and even nervous twitching.
Zinc is vital for concentration, memory, detoxification and good digestion, and when lacking, can lead to anorexia, leaky gut syndrome and digestive disease. In fact, zinc is required for many enzymatic processes in the body, yet 80% of the Australian population are estimated to be deficient in it.
The Cause Of Pyrrole Disorder
Pyrrole disorder is caused by the overproduction of hydroxyhempyrolin (HPL). The HPL binds zinc and B6 preventing their use by the body and causing excretion in the urine and hair. HPL is a biomarker for oxidative stress and is neurotoxic. Stress of any kind will increases production of pyrroles/HPL which in turn decreases zinc and B6. The reduced utilisation of zinc and B6 is what causes the symptoms of Pyrrole Disorder.
There is evidence to suggest that Pyrrole Disorder is a genetically based ailment as well as a disorder caused by a variety of lifestyle issues such as poor diet, leaky gut syndrome, stress and poor digestion. Statistics and research indicates that if a relative sufferers from Alcoholism, Schizophrenia, Depression, Bipolar Disorder or has suicided, there is a greater risk of Pyrrole Disorder in other family members.
Poor dietary choices and poor digestive health can lead to an increase in Pyrrole levels as a low nutrient diet will not deliver all of the nutrients a body needs much less one with the need for additional support. Leaky Gut Syndrome is common in sufferers of Pyrrole Disorder and a common factor for increasing blood Pyrrole levels. Consider the child with sensory processing, autism spectrum or other oral motor issues, who may have a very select array of foods they are happy to eat. If they are genetically at risk of Pyrrole, plus they eat a strict diet, and possibly have leaky gut, they can manifest the symptoms of Pyrrole disorder (but you’ve got to look at how to manage the underlying triggers of Pyrrole).
Alcohol, smoking, drugs and heavy metal exposure can dramatically increase blood pyrrole levels. This is why people who have Pyrrole Disorder will tend to get a worsening of their symptoms 24 to 48 hours after a big night out drinking or recreational drug use.
Research has discovered that stress increases the production of HPL in your blood, which in turn causes a worsening of your symptoms. It is a well known fact that high levels of cortisol (aka STRESS!) damages the intestinal wall causing intestinal inflammation. Both of which lead to an increase in Leaky Gut Syndrome. Studies have shown that zinc deficiency increases bowel permeability too. Leaky gut is not always from stress and diet, and can actually be due to a candida overgrowth, or other bacterial imbalances in the gut microbiome.
The main issue with Pyroluria is severe zinc and B6 deficiency.
Zinc is essential for 100’s of processes in the body and is particularly important for healing, immune function, digestion, neurotransmitter activation, physical growth, memory, insulin sensitivity and control of blood sugars, DNA replication, prefrontal cortex development, detoxification, and even skin health.
Zinc and B6 are essential for production of neurotransmitters such as serotonin (our happy hormone), melatonin (our sleep hormone), GABA (our relaxation hormone), and acetyl choline which is important for memory. They are also involved in production of our steroid hormones such as cortisol (our anti-inflammatory, anti-allergy hormone and stress hormone) and the conversion of oils in the body (fat metabolism, liver and gall bladder issues and weight control). The oils EPA/DHA but mostly GLA are found to be low in those with pyrrole disorder and are damaged by oxidative stress/free radicals/toxins created by pyrrole.
Common signs and symptoms of Pyrrole Disorder
White spots on fingernails
Hypoglycemia/sugar intolerance (a very common one and contributes to the Jekyll and Hyde personality often seen in someone with Pyrrole!)
Food and environmental allergies
Joint pains
Fatigue (often unexplained by other reasons, may appear as though it is “made up”)
Irritable bowel, constipation, gut pain
Dizziness
Insomnia
Poor memory and concentration
Poor stress control
Poor emotional regulation – episodic anger, or depression, may seem manic at times
ADHD or ODD in children
While you may not get all of these symptoms, or you may have all of them, it’s important to note that the level of symptoms can be effected by the severity of your zinc and B6 deficiencies, and also how you’re genetically designed.
Pyroluria reduces your absorption of zinc and B6
Information
Pyroluria
Anxiety, shyness, or fear may be common personality traits, though for some it occurs alongside other symptoms such as high stress levels, anger, poor memory and depression, and can be a lifelong struggle. Preferring small groups of close friends rather than large social groups, poor dream recall, susceptibility to allergies, fatigue, or poor sugar metabolism, can all be symptoms of a genetic disorder, which is on the rise in Australia.
Affecting up to 40% of people, it can lead to much larger problems, including a serious risk of developing addictions, alcoholism, severe depression, or psychiatric disorders. Pyroluria reduces your absorption of zinc and B6, necessary for production of brain chemicals for mood, digestion, hormone production, and to fight infections. A cascade effect toward ill health eventually develops creating emotional stress, producing cortisol and inflammation throughout the body and digestive tract. Poor digestion follows creating food sensitivities, and allowing bacterial infections to invade.
A CASCADE EFFECT TOWARD ILL HEALTH EVENTUALLY DEVELOPS
Fatigue, weight gain, fluid retention, hormone imbalance, depression and anxiety, are typical symptoms of food sensitivity, creating a secondary layer of mood effects. Further defi ciencies then develop such as iron, vitamin D, B12, leading to fatigue. Without these very important nutrients, the immune system becomes compromised, causing colds, virus, and bacterial infections, some known for creating further symptoms of depression and anxiety. The collateral damage can be vast, creating a decline into ill health and a depressive state seemingly unsolvable.
Pyroluria is simple to treat, with a rapid response time, though most people go undiagnosed. Sufferers respond poorly to common anti-depressants, so knowing that this condition affects you or your family is very important, and can be diagnosed using a simple urine test. Treating Pyroluria allows the body to repair to then successfully address stress hormones, bacterial infections, and food sensitivities, bringing your health back to its optimum state allowing you a bright healthy future, free of the symptoms of depression and anxiety.
What to Know About Pyrrole Disorder
Share on Pinterest Devon Hall/Offset Pyrrole disorder is a clinical condition that causes dramatic shifts in mood. It sometimes occurs alongside other mental health conditions, including: bipolar disorder
anxiety
schizophrenia Pyrrole disorder develops when there are too many pyrrole molecules in your body. These can strip your system of essential nutrients that play an important role in mood regulation. Doctors don’t know how common pyrrole disorder is due to lack of diagnosis. If you have symptoms or a history of mood disorders, it may be worth talking to your doctor about pyrrole testing.
What is pyrrole disorder? Hydroxyhemopyrrolin-2-one (HPL) is a molecule naturally excreted via urine. Some individuals may excrete more HPL (pyrroles) than others, which indicates a toxic level of the enzyme in their body. Previously called elevated HPL, this condition is now known as pyrrole disorder. Pyrrole molecules don’t serve any important function in the body. However, an excessive amount can cause nutritional deficiencies, particularly in zinc and vitamin B6 (pyridoxine). This is because the molecules attach themselves to these nutrients and are then excreted in urine before the body has a chance to absorb them properly. If you have too many pyrrole molecules, you may experience noticeable shifts in mood. Such changes are perhaps most noticeable in children, teenagers, and young adults.
What are the common symptoms of pyrrole disorder? Some common symptoms of pyrrole disorder include: irritability
severe anxiety
significant changes in mood
short temper (temper tantrums in younger children)
severe depression
short-term memory problems
inability to manage everyday stresses
histrionic (melodramatic) behaviors
sensitivity to loud noises, lights, or both While mood changes are perhaps the primary sign of pyrrole disorder, there are numerous physical symptoms, too. Some of the possibilities are: delayed puberty
nausea (especially in the morning)
stretch marks on the skin
pale skin that doesn’t tan easily
joint pain
leaky gut
allergies
premature graying
white spots on the nails
frequent infections
constipation
diarrhea
irritable bowel syndrome (IBS)
a “pot belly” or significant bloating
Pyrrole disorder vs. bipolar disorder It’s not uncommon for people with bipolar disorder to also have excess pyrrole molecules. However, having pyrrole disorder doesn’t necessarily mean you have bipolar disorder, too. Sometimes pyrrole disorder may be mistaken for bipolar disorder. Part of the confusion is due to the similarities in symptoms. Like pyrrole disorder, bipolar disorder causes changes in mood. These are marked by cycles of mania and depression, both of which may last for weeks at a time. Some people may have more rapid and frequent shifts in mood as part of their bipolar disorder. This is better known as rapid cycling. While not recognized as an official type of bipolar disorder, rapid cycling causes at least four or more depressive and manic episodes per year. In contrast, more traditional bipolar causes one or two. Like rapid cycling bipolar, pyrrole disorder may cause frequent changes in mood. It’s also important to consider whether you’re experiencing some of the more physical symptoms of pyrrole disorder, too.
How is pyrrole disorder diagnosed? Pyrrole disorder is diagnosed with a urine assessment called a kryptopyrrole test. The purpose is to see how many HPL molecules you have in your body. An excessive amount may indicate pyrrole disorder. You may already exhibit many of the symptoms of this disorder if your urinary pyrrole count is 20 mg/dL or above. A level of 10 to 20 mcg/dL may cause mild symptoms, if any. While the kryptopyrrole test is the only medical diagnostic test to help determine the presence of pyrrole molecules in your system, your doctor may also evaluate your overall mental health. They may ask you about any sudden shifts in mood, as well as whether you or your family have a history of certain mental health disorders.
How is pyrrole disorder treated? There’s no current medication available to treat pyrrole disorder. Instead, most therapies focus on more functional approaches that address nutrition, stress, and lifestyle. Given the role of HPL molecules in removing vitamin B6 and zinc from the body, it’s thought that supplementing these micronutrients could help treat pyrrole disorder. Other possibly helpful supplements include: omega-3 fatty acids in fish oil
magnesium
vitamin B3
vitamins C and E, to decrease oxidative cell damage While micronutrients such as vitamin B6 and zinc may be helpful in regulating your mood, some research is mixed as to whether taking these in supplemental form will reduce stress and anxiety. But when pyrrole disorder depletes these nutrients, your doctor might recommend supplements to see if your shifts in mood and other symptoms improve. If you do take supplements, it’s recommended that you stop taking them for 3 days prior to your next kryptopyrrole urine test. This will help determine whether you’re still experiencing excess HPL. Separate blood tests are needed to see if you have any nutritional deficiencies. With proper treatment, you may expect symptoms to improve within 3 to 12 weeks.
A Hidden Cause of Addictions, ADHD, and Anxiety
by Dr.Dave on Sep 4, 2017
Pyrrole disorder or pyroluria is a genetic condition in which an individual produces an abnormally large number of pyrroles. Affected individuals may have 5 – 10 times more pyrroles than are usually produced. Normally excreted in the urine, a pyrrole is a byproduct of hemoglobin synthesis and has no known function in the body.
Hemoglobin, of course, is the molecule that carries oxygen in blood. Pyrroles have an affinity for aldehydes including vitamin B6 and zinc, binding to them in large numbers. They are then excreted in the urine, meaning that the zinc and vitamin B6 nutrients are no longer available for their usual biological roles.
Relapse rates for alcoholism and other addictions are staggering. Likewise, rates of recurrence for common psychiatric disorders – including anxiety, ADHD, and depression – remain high despite aggressive treatments with modern prescription medications. These dire statistics stem from a glaring limitation of contemporary medicine: treatment focuses solely on downstream symptom relief while ignoring upstream root causes of the symptoms in question. One of the more common upstream sources of myriad psychiatric conditions is Pyroluria.
People with pyroluria have been found to have exceptionally low levels of both vitamin B6 and zinc. Deficiencies of these important nutrients have been linked to a wide range of emotional and psychiatric issues including anxiety, irritability, depression, and short-term memory problems. In addition, pyroluria is often seen in children who have been previously diagnosed with conditions characterized by poor responses to stress, behavioral disorders, learning disorders, ADHD, and autism spectrum disorders. Zinc deficiencies have been associated with physiological disorders as well: poor immune function, poor growth, and delayed puberty.
Symptoms characteristic of pyroluria:
anxiety
irritability
fatigue
poor short-term memory
little or no dream recall
mood swings
increased sensitivity to lights, sounds, odors
frequent infections
allergies
joint pain
hypoglycemia
poor appetite, especially in the morning
nausea, motion sickness
poor tolerance of dietary protein
sweet or fruity smelling breath or sweat
pale complexion
white spots on fingernails
premature graying
delayed sexual development
alcoholism
Early diagnosis and treatment are critical for successful outcomes but unfortunately, the wide range and disparate nature of symptoms contributes to frequent misdiagnosis and inappropriate treatment. The gold standard test for diagnosing pyroluria is a urine test that measures kryptopyroles:
Kryptopyrrole Pyroluria Urine Test
Because pyroluria is characterized by profound deficiencies in vitamin B6 and zinc, treatment employs nutritional rather than pharmaceutical interventions. Other nutrients are often used concurrently with vitamin B6 and zinc to enhance treatment response and may include:
Manganese – is involved in the metabolism of proteins, production of neurotransmitters, and is necessary for joint health; it is often depleted by high doses of zinc
Magnesium – helps decrease irritability and hypersensitivity to lights/sounds; taking large amounts of vitamin B6 may decrease magnesium levels
Vitamin B3 (niacinamide) – can enhance the recovery process through the production of serotonin
Vitamin C and pantothenic acid – is used to support the adrenal glands and improve energy
Individuals with pyroluria typically respond well to targeted nutritional therapies. Indeed, many patients find relief within days and most recover fully within 3-6 months with appropriate therapies. Since it is genetically-based, pyroluria is a chronic condition that requires lifelong treatment. Those who discontinue treatment generally experience an immediate return of their symptoms.
It is no accicent that our most versatile, and popular, supplement for depressed mood and anxiousness – Serocor – contains many of these all important ingredients: Vitamin B6, zinc, vitamin B3, and magnesium.
Related Products
Kryptopyrrole Pyroluria Urine Test
Serocor
Could you have Pyrrole Disorder?
Pyrrole Disorder is a relatively unknown condition, despite how many people would be suffering with it. It affects around 10% of the population, and in those suffering with other mental health issues, including schizophrenia, the prevalence is even higher. If we think of this is terms of the average classroom at school, thats 2 – 3 kids suffering with it, and often without anyone knowing.
Pyrrole Disorder comes with many symptoms, mostly related to behavioural issues and digestive complaints. These include:
– Mood swings, resulting in sudden, explosive anger and depression
– Inability to cope with stress (in both adults and children)
– Digestive complaints (irritable bowel, constipation, diarrhoea, re-occurring sore tummy)
– Sensitivity to bright lights, sounds and smells
– Inability to efficiently secrete serotonin (dubbed our ‘happy’ hormone, but involved in SO much more than that alone!)
– Sweet, fruity breath and body odour
– Motion sickness
– Insomnia + hyperactivity
If we think about the number of kids that are medicated for things like ADHD, bipolar etc – it’s worthwhile to test for Pyrrole, because many of the above symptoms can be seen as ‘bad or disruptive behaviour’, yet it may be a case of untreated Pyrrole – which is treatable with common nutrients instead of heavy duty medications which can have severe side effects.
Pyrrole disorder can also commonly lead to:
– Learning difficulties, including auditory processing disorder (making it difficult to process what you should be listening to in noisy environments – eg: a teacher in a classroom)
– Mid-morning nausea
– Not hungry for breakfast in the morning
– White spots on nails (common in zinc deficiency)
– Stretch marks (again, common in zinc deficiency)
– Anxiety, depression and pessimism
– Joint pain
Pyrrole disorder affects both adults and children alike. Generally symptoms are more severe in children, as adults tend to have developed better coping mechanisms with regards to how to manage their stress.
Pyrrole results from a blood disorder that causes dramatic zinc and B6 deficiency. Treatment of course, involves getting the balance of these nutrients corrected, and any others that may be out of whack alongside. Treatment is usually long term, and often requires time to work out the correct dosage – it definitely is not a simple case of giving these nutrients and kissing Pyrrole goodbye. Each person requires an individual dose of these nutrients, and levels may need changing at times of increased stress, for example. Other nutrients, including magnesium, beneficial oils (including fish oils and evening primrose) and antioxidants are usually part of treatment also. Things like melatonin may be used to help with sleep, as this is often a cause of concern for sufferers. Many herbal medicines can be of amazing benefit with regards to the myriad of symptoms that present in sufferers.
Treatment can be nothing short of life changing for the sufferer and their families. Testing for Pyrrole Disorder involves a simple urine test – something that can be arranged through us at Saltuary. From here, depending on levels, a nutritional supplementation plan can be devised.
If you think you may be suffering from this, or someone in your family may be, book in to see me – lets get the test done and arrange any necessary treatment from there.
With luv.. tiina xx
everything you need to know — Dr. Carrie Rigoni : Chiropractor Perth
How does Pyrrole Disorder occur?
All cells in your body produce waste or by-products. The by-product of haemoglobin is called hydroxyhemopyrrolin-2-one (HPL) also known as Pyrrole. People who have Pyrrole Disorder, produce excessive amounts of these Pyrroles which then bind to or stop use of Zinc, Vitamin B6 and Omega-6 fat GLA. Thus, these nutrients cannot be used by the body.
There are three main nutrients that are not properly absorbed in someone with pyrrole disorder. These are vitamin B6, magnesium, and zinc.
B6 in particular is necessary for the creation of red blood cells. It increases energy levels and proper cognitive function. A deficiency of B6 will often cause inflammation, depression, and sometimes anaemia.
Magnesium is often used as a muscle relaxant for athletes and is strongly involved in the blood sugar cycle. A deficiency can be the cause of blood sugar or appetite control issues, sleeplessness, constipation, and even nervous twitching.
Zinc is vital for concentration, memory, detoxification and good digestion, and when lacking, can lead to anorexia, leaky gut syndrome and digestive disease. In fact, zinc is required for many enzymatic processes in the body, yet 80% of the Australian population are estimated to be deficient in it.
The Cause Of Pyrrole Disorder
Pyrrole disorder is caused by the overproduction of hydroxyhempyrolin (HPL). The HPL binds zinc and B6 preventing their use by the body and causing excretion in the urine and hair. HPL is a biomarker for oxidative stress and is neurotoxic. Stress of any kind will increases production of pyrroles/HPL which in turn decreases zinc and B6. The reduced utilisation of zinc and B6 is what causes the symptoms of Pyrrole Disorder.
There is evidence to suggest that Pyrrole Disorder is a genetically based ailment as well as a disorder caused by a variety of lifestyle issues such as poor diet, leaky gut syndrome, stress and poor digestion. Statistics and research indicates that if a relative sufferers from Alcoholism, Schizophrenia, Depression, Bipolar Disorder or has suicided, there is a greater risk of Pyrrole Disorder in other family members.
Poor dietary choices and poor digestive health can lead to an increase in Pyrrole levels as a low nutrient diet will not deliver all of the nutrients a body needs much less one with the need for additional support. Leaky Gut Syndrome is common in sufferers of Pyrrole Disorder and a common factor for increasing blood Pyrrole levels. Consider the child with sensory processing, autism spectrum or other oral motor issues, who may have a very select array of foods they are happy to eat. If they are genetically at risk of Pyrrole, plus they eat a strict diet, and possibly have leaky gut, they can manifest the symptoms of Pyrrole disorder (but you’ve got to look at how to manage the underlying triggers of Pyrrole).
Alcohol, smoking, drugs and heavy metal exposure can dramatically increase blood pyrrole levels. This is why people who have Pyrrole Disorder will tend to get a worsening of their symptoms 24 to 48 hours after a big night out drinking or recreational drug use.
Research has discovered that stress increases the production of HPL in your blood, which in turn causes a worsening of your symptoms. It is a well known fact that high levels of cortisol (aka STRESS!) damages the intestinal wall causing intestinal inflammation. Both of which lead to an increase in Leaky Gut Syndrome. Studies have shown that zinc deficiency increases bowel permeability too. Leaky gut is not always from stress and diet, and can actually be due to a candida overgrowth, or other bacterial imbalances in the gut microbiome.
The main issue with Pyroluria is severe zinc and B6 deficiency.
Zinc is essential for 100’s of processes in the body and is particularly important for healing, immune function, digestion, neurotransmitter activation, physical growth, memory, insulin sensitivity and control of blood sugars, DNA replication, prefrontal cortex development, detoxification, and even skin health.
Zinc and B6 are essential for production of neurotransmitters such as serotonin (our happy hormone), melatonin (our sleep hormone), GABA (our relaxation hormone), and acetyl choline which is important for memory. They are also involved in production of our steroid hormones such as cortisol (our anti-inflammatory, anti-allergy hormone and stress hormone) and the conversion of oils in the body (fat metabolism, liver and gall bladder issues and weight control). The oils EPA/DHA but mostly GLA are found to be low in those with pyrrole disorder and are damaged by oxidative stress/free radicals/toxins created by pyrrole.
Common signs and symptoms of Pyrrole Disorder
White spots on fingernails
Hypoglycemia/sugar intolerance (a very common one and contributes to the Jekyll and Hyde personality often seen in someone with Pyrrole!)
Food and environmental allergies
Joint pains
Fatigue (often unexplained by other reasons, may appear as though it is “made up”)
Irritable bowel, constipation, gut pain
Dizziness
Insomnia
Poor memory and concentration
Poor stress control
Poor emotional regulation – episodic anger, or depression, may seem manic at times
ADHD or ODD in children
While you may not get all of these symptoms, or you may have all of them, it’s important to note that the level of symptoms can be effected by the severity of your zinc and B6 deficiencies, and also how you’re genetically designed.
Pyroluria and Adrenal Fatigue Syndrome
Pyroluria is a genetically inherited but correctable biochemical imbalance involving an abnormality in hemoglobin synthesis. It can be purely genetic or acquired through environmental and emotional stress and especially from leaky gut syndrome and the overuse of antibiotics. Charles Darwin is thought to be afflicted by this condition.
Pyroluria is known by many different names including Pyrrole Disorder, Kryptopyrrole, Kryptopyrroluria, Pyrroluria, Pyrolle Disorder, Mauve Factor and Hemepyrrole.
What is Pyroluria?
Pyroluria is a blood disorder first and foremost. Hemoglobin is a particular protein whose job it is to keep and maintain iron in red blood cells. Because of an abnormality in the synthesis of hemoglobin, a by-product is created called kryptopyrrole, known scientifically as hydroxyhemoppyrrolin-2-one (HPL). This is the chemical that is involved in the production of heme, the substance that causes blood to be red in color. In most humans, HPL causes no problems and is simply excreted from the body via the urine.
With pyroluria, the level of pyrroles/HPL in the blood is abnormally high, and as a result, the receptor sites for Vitamin B6 and zinc are bound up and blocked. Kryptopyrroles target aldehydes in order to bind to them, and specifically targets pyridoxine (Vitamin B6). Together they attach to zinc, which creates a complex that is ultimately eliminated through the urine. If there is excessive binding and excretion out of the body, Vitamin B6 and zinc may be deficient.
Zinc and B6 are essential for the production of neurotransmitters such as serotonin (our happy hormone), melatonin (our sleep hormone), GABA (our calming hormone), and acetylcholine (our housekeeping hormone). They are also involved in the production of our steroid hormones such as cortisol (our anti-stress hormone) and the conversion of oils in the body (fat metabolism, liver, gall bladder issues, and weight control).
Triggers of Pyroluria
The condition usually presents itself in the late teens and persists throughout the balance of the person’s life. Any stressful experience can trigger the condition to be symptomatic because stress increases the production of pyrroles. They include:
Poor dietary choices and poor digestive health as a poor diet and digestion robs your body of essential nutrients.
Those with leaky gut syndrome are particularly vulnerable.
Prolonged laxative use, especially those containing magnesium sulfate and bisacodyl (a laxative drug), increases leaky gut syndrome. Frequent use of enemas (especially soap suds and tap water) result in loss of the intestinal lining, leading to leaky gut. Excessive stress also adds to this burden.
Unhealthy lifestyle habits, including excessive intake of alcohol, smoking, and drugs, can dramatically increase blood pyrrole levels as well. This is why sufferers of pyroluria tend to get a worsening of their symptoms twenty-four to forty-eight hours after a big alcohol party or recreational drug use.
Neurobehavioral Disorders Linked to High Levels of HPL
Pyroluria, elevated pyrroles, or a high kryptopyrrole in laboratory test results are frequently associated and identified in behavior disorders, autism, ADHD, Asperger’s, anxiety, ADD, depression, bipolar disorders, aggressive behavior, schizophrenia and other mental and emotional conditions.
It can also create poor tolerance of physical and emotional stress, poor anger control, emotional mood swings, anxiety, frequent infection, inability to tan, poor dream recall, poor short-term memory, abnormal fat distribution, sensitivity to light and sound, as well as tactile sensitivities.
About 10 percent of the population at large has the disorder. Only a small percentage of those afflicted has clinical symptoms. There is as many as 20 percent of those under psychiatric care suffering from pyroluria. It is estimated that 40 percent of patients diagnosed with schizophrenia have the condition. It affects women more than men.
Physical characteristics associated with Pyroluria:
Acne, eczema, or herpes
Coarse eyebrows and lack of hair on head, eyebrows and eyelashes
Cold hands and feet
White spots on fingernails (zinc deficiency)
Paper thin skin
Creaking knees
Fat concentrated in mid-section
Increased number of stretch marks
Poor tooth enamel
Sweet fruity smelling breath
Symptoms of Pyroluria
Pyrroles are classed as nerve poisons and as such can cause damage to nerves, nerve cells and tissue, and the brain, affecting the transmission of information by nerves. Symptoms of pyroluria, therefore, spread across a broad spectrum. Because they are rather subtle, most are easily missed unless one is on the lookout. They include acne, allergies to food and the environment, anemia, anxiety and nervousness, delayed onset of puberty, delusions and hallucinations, unexplained chills and fever, poor sense of smell or taste, depression, digestive disturbances (constipation, abnormal tenderness), outbursts of temper, fatigue, glucose intolerance/hypoglycemia, gluten intolerance, and hyperactivity. The list continues with insomnia, irregular menstruation in females, increases in sensitivity or intolerance to light, sunlight and sound, crowded front teeth, irritable bowel syndrome, joint pain in knees and legs, loss of appetite, brain fog, low tolerance to stress, memory loss, poor dream recall, restless leg syndrome, sensitivity to medications, social withdrawal, and many more.
Do not be overwhelmed. No single person has all the signs and symptoms. The key to recognizing pyroluria is to detect a pattern of nonspecific symptoms pointing to an underlying general discontent of the body accompanied by a relevant history.
Diagnosing Pyroluria
Though having been around since the beginning of civilization, Adrenal Fatigue Syndrome (AFS), pyroluria, mitochondrial disease, and methylenetetrahydrofolate reductase (MTHFR) are some conditions coming to the forefront of scientific investigations because laboratory tools are now available to validate its scientific merit.
A qualified medical practitioner, after reviewing the complete medical and psychiatric history, will start the workup with a urine test for excess kryptopyrroles. Most have less than 10 mcg/dL of KPU. Persons with 10-20 mcg/dl are considered to have borderline pyroluria and may still benefit from treatment. Persons with levels above 20 mcg/dl are considered to have pyroluria. Some have levels in the hundreds.
If a person has been taking B6 and zinc, then the urine test can show a negative reading or a lower reading than if they were not taking the supplements. This is because the pyrroles will be bound and in a non-detectable form.
In order to treat the pyroluria nutritionally, further tests may be needed, including zinc and copper.
Bear in mind that blood measurements of B6 or zinc is not an accurate way of making this diagnosis as that is highly variable on vitamin intake or diet. Just having a deficiency in these nutrients doesn’t in itself cause an increase in pyrroles. It is rather a faulty enzyme pathway in the liver that causes them to increase.
The differential diagnosis should include Adrenal Fatigue Syndrome, histapenia (low histamine), histadelia (high histamine), and hypercupremia (high copper). There is also a rare genetic condition called acute intermittent porphyria (AIP), which is very severe and quite similar that is often linked with pyroluria. The fact is that of AIP patients tested, 100 percent of them showed positive results for having pyroluria.
Clinical presentation of pyroluria ranges from mild to severe. It depends on the genotype and the level of toxins exposed to in their environment and stress level. Concurrent presence of genetic defects like histapenia, histadelia and hypercupremia mentioned above further complicates the clinical presentation. As a result, symptoms do vary greatly among individuals across a wide spectrum.
Remember that just because one has clinical signs of pyroluria as well as positive laboratory tests does not mean that treatment is necessary. The vast majority of people with pyroluria are in fact asymptomatic and live normal lives.
Treatments for Pyroluria
Because the treatment is metabolic rather than pharmacologic, treatment needs to be titrated to individual requirements. The first thing to do nutritionally is to take more supplements of zinc and Vitamin B6 than is stated as the daily average requirement. This will compensate for the deficits resulting from this condition. These are essential nutrients, which will reduce the amount of HPL excreted, therefore improving all neurobehavioral symptoms linked with having these deficits.
The recommended forms for these nutritional supplements are specifically zinc picolinate and pyridoxal-5-phosphate (P5P).
Vitamin B6 is naturally found in our food in three different forms: pyridoxamine, pyridoxine, and pyridoxal. The last one, pyridoxal is the one that joins with a phosphate forming the metabolically active coenzyme, which is used in our bodies. This is called P5P. The most commonly used supplement of Vitamin B6 is pyridoxine hydrochloride and most people find this very useful. But with this supplement the body still needs to convert the pyridoxine in the small intestine into P5P so that it can be utilized.
The body cannot directly use pyridoxine. The metabolic processes that must take place first are called phosphorylation and oxidation. For these processes to take place, they need riboflavin (Vitamin B2), zinc and magnesium. They should be considered.
Recommended Supplements for Healthy People with Pyroluria
The higher the pyrrole level, the higher the need for B6 and zinc to bind and clear it safely from the body as well as replete the deficiency state that can cause many symptoms.
Vitamin B6: 50-300 mg of P5P and 200-400 mg of pyridoxine hydrochloride. Vitamin B6 is converted (metabolized) into P5P although taking the P5P metabolite can have a stronger effect than B6 and avoid the risk of a B6 overdose. P5P has been found to be most effective if taken every three to four hours during the day in doses of 10 to 20 mg each. Because P5P is water-soluble it is easily depleted and cannot be stored in the body. This is especially true for people who drink coffee or tea or anything else having a diuretic effect.
50-300 mg of P5P and 200-400 mg of pyridoxine hydrochloride. Vitamin B6 is converted (metabolized) into P5P although taking the P5P metabolite can have a stronger effect than B6 and avoid the risk of a B6 overdose. P5P has been found to be most effective if taken every three to four hours during the day in doses of 10 to 20 mg each. Because P5P is water-soluble it is easily depleted and cannot be stored in the body. This is especially true for people who drink coffee or tea or anything else having a diuretic effect. Zinc Picolinate: 25-75 mg of zinc picolinate daily is recommended for adults with severe cases of pyroluria. It should be taken after breakfast in the morning. Dosages of zinc need to be increased slowly, building up in the system according to lab results measuring levels of zinc, copper and ceruloplasmin, as well as the level of HPL in the urine. Another consideration is the vitality of the patient and their ability to adapt and in general cope with chelation therapy.
25-75 mg of zinc picolinate daily is recommended for adults with severe cases of pyroluria. It should be taken after breakfast in the morning. Dosages of zinc need to be increased slowly, building up in the system according to lab results measuring levels of zinc, copper and ceruloplasmin, as well as the level of HPL in the urine. Another consideration is the vitality of the patient and their ability to adapt and in general cope with chelation therapy. Copper: Excessive imbalance is common in those with pyroluria and needs to be detoxified. It is advisable to have mineral and metal levels checked in complicated cases as well.
in those with pyroluria and needs to be detoxified. It is advisable to have mineral and metal levels checked in complicated cases as well. Manganese: This vital nutrient is depleted when zinc is taken at the high levels that are necessary for overcoming pyroluria. Manganese is necessary for the metabolism of certain proteins; it is also important to joint development and neurotransmitter production.
This vital nutrient is depleted when zinc is taken at the high levels that are necessary for overcoming pyroluria. Manganese is necessary for the metabolism of certain proteins; it is also important to joint development and neurotransmitter production. Magnesium: Taking B6 in large amounts can deplete magnesium levels. Adding magnesium can reduce irritability and hypersensitivity to light and sound, reducing chances of peripheral nerve sensitivity, helping the body to calm down, promoting better sleep, and reducing constipation. The liposomal form is preferred.
Taking B6 in large amounts can deplete magnesium levels. Adding magnesium can reduce irritability and hypersensitivity to light and sound, reducing chances of peripheral nerve sensitivity, helping the body to calm down, promoting better sleep, and reducing constipation. The liposomal form is preferred. Niacinamide (Vitamin B3): This nutrient is necessary for the production of tryptophan, which in turn is necessary for the production of serotonin. Taking niacinamide helps to speed the pyroluria recovery process. Compared to niacin, niacinamide does not cause skin flushes.
This nutrient is necessary for the production of tryptophan, which in turn is necessary for the production of serotonin. Taking niacinamide helps to speed the pyroluria recovery process. Compared to niacin, niacinamide does not cause skin flushes. Vitamin C and Pantothenic Acid: These nutrients help to rebuild adrenal glands that become exhausted from coping with the ongoing tension caused by pyroluria; adding them to pyroluria supplementation allows patients to overcome the weakness and fatigue they often feel.
All nutritional supplements should be titrated professionally to each person’s body weight, age, lab results, symptom severity and their ability to absorb the supplements. Other considerations would be if the patient were suffering from any underlying digestive disorders affecting their ability to absorb nutrients. Disorders such as: Coeliac disease, Crohn’s disease, food allergies or intolerances, gastritis, GI Tract infections such as clostridia, H. pylori, parasites, or yeast, inflammatory bowel disease, intestinal dysbiosis, which is an imbalance of the flora in the bowel, irritable bowel syndrome, leaky gut syndrome, and/or peptic ulcer.
If there is a pre-existing deficiency of zinc and Vitamin B6 then secondary deficiencies should be addressed, since these nutrients are vital for the production of certain other nutrients, hormones, neurotransmitters and over one hundred different enzymatic reactions in the body.
Those with a history of liver pathology or congestion need to be especially careful using the right dosage of Vitamin B6 and zinc due to possible faulty liver cytochrome P450 metabolic detoxification pathways within that leads to a higher internal pyrrole load.
Prognosis
Normal healthy people without food allergies, methylation issues, underlying chronic illness, internal chemical imbalances, or digestive disorders can see improvement within a short time, sometimes within days, by only supplementing with the right dose of Vitamin B6 and zinc. The result can be quite dramatic. In fact, experienced clinicians will often proceed with a clinical trial of B6 and zinc if there is suspected polyuria and the right clinical conditions are met. There is often no need for laboratory testing prior to the clinical trial.
Healthy people with severe pyroluria usually require several weeks before progress is seen and improvement may be gradual over three to twelve months. Features of pyroluria usually recur within two to four weeks if the nutritional program is stopped. Thus, the need for treatment is indefinite.
People who are constitutionally weak or have underlying chronic illness fare differently. They usually do not respond with the normal expected outcome and may in fact get worse. Those that have underlying Adrenal Fatigue Syndrome can find this often challenging.
Pyroluria and Adrenal Fatigue Syndrome
Adrenal Fatigue Syndrome (AFS) is a stress induced neuro-endocrine dysfunction of the body. The hallmark symptom is fatigue of unknown origin despite normal medical investigation. There are four clinical stages of clinical progression, from mild to severe. In advanced stages, one can be incapacitated and housebound, unable to work or lead a normal social life. In some of these stages, the effects include symptoms similar to pyroluria.
Most people with AFS carry on a normal life and are thus unaware of the potential natural progression of this condition until quite late. Allopathic physicians are ignorant of this condition and thus reject its notion. Do not be surprised if your doctor tells you AFS does not exist.
Many symptoms of pyroluria and AFS are similar because both have close ties to the psycho-neuro-endocrine system. The key symptoms include fatigue, insomnia, irritable bowl, anxiety and nervousness, depression, increase in sensitivity or intolerance to temperature change or external stimuli, anxiety, depression, brain fog, low tolerance to stress, and sensitivity to medications and supplements.
Pyroluria Treatment and Maximum Tolerance Level
Once pyroluria is suspected or confirmed by laboratory testing, most are started on Vitamin B6 and zinc therapy by their physician with high hopes. From our experience, it is rare that B6 and zinc therapy alone lead to an immediate, sustained, and complete recovery of all symptoms of pyroluria when AFS is present or when the body is very weak from other chronic conditions. Obviously, something is amiss.
With concurrent AFS, the body clinically responds to vitamin B6 and zinc therapy with heightened sensitivity similar to how it reacts when the external substrate approaches its internal maximum tolerance level (MTL). Substrates can be medications, nutritional supplements, and selected types of food. The body has a pre-established MTL for each compound. Once reached, the body will try to get rid of the excess automatically. For example, in the case of magnesium or Vitamin C, loose bowel can ensue as the body tries to get rid of it. Different substrates are cleared through different mechanisms. The liver is largely responsible for this job. If not cleared or at least cleared in a timely fashion, say in the case of liver congestion or extracellular matrix pollution, metabolic byproducts can accumulate in the body and become toxic. Circulation of such toxic compounds to the various parts of the body can lead to brain fog, joint pain, irritability, anxiety, insomnia, and cramps.
The body’s overall sensitivity to substrates increases as it gets closer to the MTL. There may be subtle signs of intolerance such as bloating, loose stools, feeling jittery, and insomnia. These are warning signs. If exceeded, the MTL then activates the body’s alert system and initiates steps to rid itself of the excess aggressively. In this alert process, the autonomic nervous system is usually involved, triggering the release of norepinephrine and adrenaline (epinephrine). These powerful hormones lower the threshold for paradoxical reaction and tolerance to stress, medications and supplements.
Forcing more Vitamin B6 and zinc without consideration to the MTL will only worsen the situation as they will wire the body internally and trigger worsening fatigue, anxiety, insomnia, and other undesirable symptoms.
Compounds that can potentiate the stimulatory effect of B6 and zinc include selenium, copper, manganese, calcium, kelp, iodine, high dose amino acid, and other members of the Vitamin B family. Also included in this effect are adrenal and thyroid glandular, adaptogenic herbs such as ashwagandha, licorice, and rhodiola, which can compound the problem. Those on thyroid hormone replacement therapy, testosterone, DHEA, pregnenolone and bioidentical hormonal therapy need to be extremely careful as well. The addition of Vitamin B6 and zinc to the regiment may hasten sensitivity and can lead to overstimulation and ultimately therapeutic failure.
Therefore, despite high hopes of successful pyroluria treatment, the vast majority will find their clinical outcome less than ideal and sub-optimal, especially if they are already on a basket of different nutritional supplements mentioned above as stimulatory. The more advanced the AFS, the greater the risk of therapeutic failure.
While those in mild AFS may experience consistent benefit, most in advanced stages will feel only a slight improvement of energy at best after a few weeks or months of therapy, with their energy rise plateauing as fatigue resurges. Energy recovery generally falls below expectations and targets for these. Many in advanced AFS do not improve at all and feel no difference. Some, in fact, feel worse right from the start or soon afterward, especially those who are very weak, incapacitated, or in a catabolic state. The overall clinical picture is often muddy at best over time.
Who Responds Well?
Those who respond positively to B6 and zinc alone usually are young, constitutionally strong, and in early stages of AFS, where fatigue is mild and not incapacitating. Positive results are usually felt within weeks and sustainable over time indefinitely. After a while, dosage can be reduced without sacrificing results.
If you are in advanced stages of AFS or internally weak, be very careful commencing zinc and B6 therapy even if your laboratory test for pyroluria is positive. Forcing zinc and B6 into the body under these circumstances is a common recovery mistake.
Unless there is primary pyroluria and no other associated chronic disease that weakens the body, healing the adrenals first can often lead to spontaneous recovery of most if not all symptoms of pyroluria. Attempts to heal the pyroluria without concurrent attention to AFS can retard the healing process of both.
When Laboratory Results can be Misleading
Relying on laboratory results alone to start treatment may be acceptable for those in early stages of AFS where symptoms are relatively mild and the body is strong. Do not embark on an aggressive treatment program by relying on laboratory results alone if you are in advanced stages of AFS. Vitamin B6 and zinc can be adrenal crash triggers in such cases.
Unless there is a very clear indication of Vitamin B6 and zinc therapy, many factors have to be considered prior to commencing aggressive therapy. Most sufferers of AFS are so eager to try Vitamin B6 and zinc that they overlook considering the potential negative outcome as part of their overall decision making. They are emotionally devastated when clinical results do not meet their expectations as they get worse overall instead of better.
When Good is Bad
Using any nutritional supplementation for AFS or pyroluria recovery should proceed slowly and under professional care. Any immediate drastic improvement of fatigue after using B6 and zinc is not necessarily a good sign. It can be a sign of impending substrate saturation as MTL is reached. Hypersensitivity, paradoxical effect, worsening fatigue, intolerance and adrenal crashes can result if advanced AFS is present.
A significant immediate positive outcome can also be, but not always, an alert of underlying liver dysfunction, extracellular matrix congestion, feedback loop dysregulation, or hypersensitivity of receptor sites as the body overreacts and amplifies the therapeutic response. Always be on the lookout for any drastic clinical change, whether it is positive or negative. Both can point to underlying dysfunction.
The Adrenals Come First
Once diagnosed or suspected of pyroluria, especially when advanced AFS is present, the temptation to start on B6 and zinc immediately should be refrained. Stabilize and strengthen the adrenals first. This will reduce the chances of adrenal crashes triggered by pyroluria therapy.
Our comprehensive total body approach can usually stabilize and bring healing to weak adrenals within weeks, though those with liver and extracellular matrix congestion may need significantly more time. Fatigue should begin to reduce once the healing process starts. If pyroluria is also present, symptoms should also subside automatically as adrenal healing progresses. No Vitamin B6 or zinc is then necessary.
Once the adrenals are stable and well-healed, a trial course of Vitamin B6 and zinc can be considered as a way to speed up the AFS recovery process, with dosage titrated carefully. If pyroluria is indeed a concurrent problem, it will be corrected automatically. B6 and zinc helps both AFS and pyroluria without the risk of adrenal crashes when given at the right time and dosage. Jumping in too early can worsen the overall fatigue.
One has closely monitored any change in clinical symptoms and made dosage and delivery system adjustments accordingly.
Summary
Pyroluria (Pyrrole disorder) is characterized by an elevated urine kryptopyrrole, which results in a dramatic deficiency of zinc and Vitamin B6. It is a blood disorder, which is genetically transmitted. Because of an abnormality in the synthesis of hemoglobin, a chemical imbalance occurs in the blood. Diagnosis can be made by urine laboratory testing. Treatment consists of Vitamin B6 and zinc. The decision of whether treatment is needed varies. The majority of sufferers are asymptomatic with no treatment needed. The symptoms of pyroluria and AFS are similar. Our clinical experience has shown that treatment for pyroluria is best deferred until the adrenals are well healed in sufferers that are in advanced stages of AFS. Too aggressive an approach with pyroluria wrongly timed can worsen AFS and trigger adrenal crashes.
Dr. Lam’s Key Questions
Is Adrenal Fatigue related to Alzheimer’s? There should be no correlation.
What to Know About Pyrrole Disorder
Share on Pinterest Devon Hall/Offset Pyrrole disorder is a clinical condition that causes dramatic shifts in mood. It sometimes occurs alongside other mental health conditions, including: bipolar disorder
anxiety
schizophrenia Pyrrole disorder develops when there are too many pyrrole molecules in your body. These can strip your system of essential nutrients that play an important role in mood regulation. Doctors don’t know how common pyrrole disorder is due to lack of diagnosis. If you have symptoms or a history of mood disorders, it may be worth talking to your doctor about pyrrole testing.
What is pyrrole disorder? Hydroxyhemopyrrolin-2-one (HPL) is a molecule naturally excreted via urine. Some individuals may excrete more HPL (pyrroles) than others, which indicates a toxic level of the enzyme in their body. Previously called elevated HPL, this condition is now known as pyrrole disorder. Pyrrole molecules don’t serve any important function in the body. However, an excessive amount can cause nutritional deficiencies, particularly in zinc and vitamin B6 (pyridoxine). This is because the molecules attach themselves to these nutrients and are then excreted in urine before the body has a chance to absorb them properly. If you have too many pyrrole molecules, you may experience noticeable shifts in mood. Such changes are perhaps most noticeable in children, teenagers, and young adults.
What are the common symptoms of pyrrole disorder? Some common symptoms of pyrrole disorder include: irritability
severe anxiety
significant changes in mood
short temper (temper tantrums in younger children)
severe depression
short-term memory problems
inability to manage everyday stresses
histrionic (melodramatic) behaviors
sensitivity to loud noises, lights, or both While mood changes are perhaps the primary sign of pyrrole disorder, there are numerous physical symptoms, too. Some of the possibilities are: delayed puberty
nausea (especially in the morning)
stretch marks on the skin
pale skin that doesn’t tan easily
joint pain
leaky gut
allergies
premature graying
white spots on the nails
frequent infections
constipation
diarrhea
irritable bowel syndrome (IBS)
a “pot belly” or significant bloating
Pyrrole disorder vs. bipolar disorder It’s not uncommon for people with bipolar disorder to also have excess pyrrole molecules. However, having pyrrole disorder doesn’t necessarily mean you have bipolar disorder, too. Sometimes pyrrole disorder may be mistaken for bipolar disorder. Part of the confusion is due to the similarities in symptoms. Like pyrrole disorder, bipolar disorder causes changes in mood. These are marked by cycles of mania and depression, both of which may last for weeks at a time. Some people may have more rapid and frequent shifts in mood as part of their bipolar disorder. This is better known as rapid cycling. While not recognized as an official type of bipolar disorder, rapid cycling causes at least four or more depressive and manic episodes per year. In contrast, more traditional bipolar causes one or two. Like rapid cycling bipolar, pyrrole disorder may cause frequent changes in mood. It’s also important to consider whether you’re experiencing some of the more physical symptoms of pyrrole disorder, too.
How is pyrrole disorder diagnosed? Pyrrole disorder is diagnosed with a urine assessment called a kryptopyrrole test. The purpose is to see how many HPL molecules you have in your body. An excessive amount may indicate pyrrole disorder. You may already exhibit many of the symptoms of this disorder if your urinary pyrrole count is 20 mg/dL or above. A level of 10 to 20 mcg/dL may cause mild symptoms, if any. While the kryptopyrrole test is the only medical diagnostic test to help determine the presence of pyrrole molecules in your system, your doctor may also evaluate your overall mental health. They may ask you about any sudden shifts in mood, as well as whether you or your family have a history of certain mental health disorders.
How is pyrrole disorder treated? There’s no current medication available to treat pyrrole disorder. Instead, most therapies focus on more functional approaches that address nutrition, stress, and lifestyle. Given the role of HPL molecules in removing vitamin B6 and zinc from the body, it’s thought that supplementing these micronutrients could help treat pyrrole disorder. Other possibly helpful supplements include: omega-3 fatty acids in fish oil
magnesium
vitamin B3
vitamins C and E, to decrease oxidative cell damage While micronutrients such as vitamin B6 and zinc may be helpful in regulating your mood, some research is mixed as to whether taking these in supplemental form will reduce stress and anxiety. But when pyrrole disorder depletes these nutrients, your doctor might recommend supplements to see if your shifts in mood and other symptoms improve. If you do take supplements, it’s recommended that you stop taking them for 3 days prior to your next kryptopyrrole urine test. This will help determine whether you’re still experiencing excess HPL. Separate blood tests are needed to see if you have any nutritional deficiencies. With proper treatment, you may expect symptoms to improve within 3 to 12 weeks.
What to Avoid Having Pyroluria Disorder
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If you’re ready to start your healing journey, schedule your free one-on-one consultation to discuss your current mental and/or physical health challenges, history, and desired health goals. Take the first step on your healing journey today.
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